Silk Fibroin Crosslinked Glycyrrhizic Acid and Silver Hydrogels for Accelerated Bacteria-Infected Wound Healing

Antibacterial hydrogels are intensively studied as wound dressings. Silk fibroin (SF) is chemical crosslinked to glycyrrhizic acid (GA) and silver to fabricate a hydrogel dressing with both antibacterial and anti-inflammatory properties. The SF/Ag/GA hydrogel exhibits high water content with acceptable mechanical properties, combines the good biocompatibility and biodegradability of SF, the antibacterial activity of silver, and the anti-inflammatory property of GA, capable to promote tissue regeneration during wound healing process, offering great potential as an alternative for wound dressings.