Expression of Zinc-Finger Antiviral Protein in hCMEC/D3 Human Cerebral Microvascular Endothelial Cells: Effect of a Toll-Like Receptor 3 Agonist.

Neuroimmunomodulation(2022)

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摘要
ZAPL and ZAPS were expressed in hCMEC/D3 cells, and ZAPS expression was upregulated by poly IC. IRF3 and TRIM25 are involved in poly IC-induced upregulation of ZAPS. ZAP may contribute to antiviral reactions in brain microvascular endothelial cells and protect the brain from invading viruses such as JEV.
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关键词
Brain microvascular endothelial cells,IFN regulatory factor 3,Toll-like receptor 3,Tripartite motif protein 25,Zinc-finger antiviral protein
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