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Species-selective Targeting of Pathogens Revealed by the Atypical Structure and Active Site of Trypanosoma Cruzi Histone Deacetylase DAC2.

Martin Marek,Elizabeth Ramos-Morales, Gisele F. A. Picchi-Constante,Theresa Bayer,Carina Norstrom,Daniel Herp, Policarpo A. Sales-Junior,Eloise P. Guerra-Slompo,Kristin Hausmann,Alokta Chakrabarti,Tajith B. Shaik,Annika Merz,Edouard Troesch,Karin Schmidtkunz,Samuel Goldenberg,Raymond J. Pierce,Marina M. Mourao,Manfred Jung,Johan Schultz,Wolfgang Sippl,Nilson I. T. Zanchin,Christophe Romier

Cell Reports（2021）

Cited 12|Views26
Key words
histone deacetylases,eukaryotic parasites,Trypanosoma cruzi,functional essentiality,atypical three-dimensional structure,chemical inhibition
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