Anti-CCR9 CAR-T Cells for T Acute Lymphoblastic Leukemia

The prognosis of relapsed/refractory T acute lymphoblastic leukemia (T-ALL) is poor with a dire lack of new treatment options which impart meaningful survival benefits. This is in stark contrast with B-ALL, where CD19-directed CAR-T cell therapy has revolutionized the treatment of relapsed/ refractory (r/r) disease. However, CAR-T for T-ALL is challenging since target antigens described to date are expressed on normal T cells. This leads to two main problems: loss of essential normal T cells and self-kill ‘fratricide’ of CAR-T.