Neuregulin-1 enhances cell-cycle activity, delays cardiac fibrosis, and improves cardiac performance in rat pups with right ventricular pressure load.

Guido P L Bossers,Marie Günthel,Diederik E van der Feen,Quint A J Hagdorn,Anne-Marie C Koop,Karel van Duijvenboden,Phil Barnett,Marinus A J Borgdorff,Vincent M Christoffels,Herman H W Silljé,Rolf M F Berger,Beatrijs Bartelds

The Journal of thoracic and cardiovascular surgery（2022）

引用 4|浏览24

暂无评分

摘要

RV PL during growth induces a transient CCA increase. Further CCA stimulation improves cardiac function and delays fibrosis. This proof-of-concept study shows that stimulation of CCA can improve RV adaptation to PL in the postnatal developing heart and might provide a new approach to preserve RV function in patients with congenital heart disease.

查看译文

关键词

heart failure,neuregulin-1,pressure load,proliferation,right ventricle

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要