Mechanistic Models of COVID-19: Insights into Disease Progression, Vaccines, and Therapeutics
International Journal of Antimicrobial Agents（2022）
Abstract
•COVID-19 virus dynamics models capture disease trajectories across populations.•Models yield insights into heterogeneity of infection severity and immune responses.•QSP models allow optimization of immunomodulatory agents, antivirals, and vaccines.
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Key words
SARS-CoV-2,COVID-19,Antiviral therapeutics,Vaccines,Quantitative systems pharmacology,Viral dynamics models
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