ATM modulates subventricular zone neural stem cell maintenance and senescence through Notch signaling pathway

Chuanming Dong,Xianli Wang,Lixin Sun,Liang Zhu,Danjing Yang,Shane Gao,Wenjun Zhang,Bin Ling,Aibin Liang,Zhengliang Gao,Jun Xu

Stem Cell Research（2022）

引用 7|浏览9

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摘要

•DNA damage accumulation increased in ATM deficient neural progenitor cells.•ATM is essential for maintaining the stemness of adult NSCs.•ATM deficiency accelerates NSC senescence.•Whole-genome transcriptomic analysis unravels Notch signaling pathway as a key regulator for NSC maintenance.•Notch activation inhibit the abnormal proliferation of ATM–/– neural stem cells.

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关键词

ATM,Neural stem cell,Notch signaling pathway,Quiescence,Aging

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