Diagnostic performance of the bladder epichecktm methylation test and photodynamic diagnosis guided cystoscopy in surveillance of high risk non-muscle invasive bladder cancer: results of a single center, prospective, blinded clinical trial

•Bladder EpiCheck is a very accurate diagnostic tool for bladder cancer.•Bladder EpiCheck could be used in the follow-up of high-risk bladder cancer in association with urinary cytology.•Bladder EpiCheck could reduce the number of cystoscopies in the follow-up.•Standard follow-up of bladder cancer is affected by some significant limitation.