Total synthesis of remdesivir

Kishore Kumar Palli,Palash Ghosh,Shiva Krishna Avula,B Sridhara Shanmukha Rao,Amol D Patil,Subhash Ghosh,Gangarajula Sudhakar,Chada Raji Reddy,Prathama S Mainkar,Srivari Chandrasekhar

TETRAHEDRON LETTERS（2022）

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摘要

Remdesivir, the first drug approved by the FDA to treat COVID-19, is in high demand for patients infected with the SARS-CoV-2 virus. Herein, we report a facile approach minimizing the protecting group manipulations to afford remdesivir in good overall yield. (c) 2021 Elsevier Ltd. All rights reserved.

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关键词

Remdesivir, Nucleotide, Nucleoside, COVID-19, RdRp

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