Complement ratios C3bc/C3 and sC5b-9/C5 do not increase the sensitivity of detecting acute complement activation systemically

Anub Mathew Thomas,Viktoriia Chaban,Søren E Pischke,Hilde Lang Orrem,Vidar Bosnes,Kjetil Sunde,Ingebjørg Seljeflot,Christofer Lundqvist,Espen Rostrup Nakstad,Geir Øystein Andersen,Camilla Schjalm,Tom Eirik Mollnes,Andreas Barratt-Due

Molecular Immunology（2022）

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摘要

•The complement activation markers C3bc and sC5b-9 were sensitive markers of complement activation in acute clinical settings.•Increased C3bc/C3- and sC5b-9/C5 ratios are vastly dependent on C3bc and sC5b-9.•Complement ratios C3bc/C3 and sC5b-9/C5 do not increase the sensitivity of detecting systemic complement activation.

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关键词

Complement activation products,Ratio,C3bc,sC5b-9,Complement,Systemic compplement activation

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