Visualization of mitophagy using LysoKK, a 7-nitro-2,1,3-benzoxadiazole-(arylpropyl)benzylamine derivative

Hiroshi Takemori,Kenichi Koga,Kyoka Kawaguchi,Saho Furukawa, Seiya Ito, Jun Imaishi,Miyu Watanabe,Miwa Maeda,Momoka Mizoguchi,Kentaro Oh-Hashi,Yoko Hirata,Kyoji Furuta

Mitochondrion（2022）

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摘要

•LysoKK/GIF2259, a 7-Nitro-2,1,3-benzoxadiazole (NBD) derivative, is a new lysosome probe.•The combination of LysoKK/GIF2259 with MitoMM2 (mitochondria probe) can monitor mitophagy easily.•CCCP induces mitochondrial exchange in 24 h.

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关键词

Live imager,Endosome,Lysosome,Mitophagy,Phospholipid,Autophagy

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