Total Synthesis of Paclitaxel

Shota Iiyama,Keisuke Fukaya,Yu Yamaguchi,Ami Watanabe,Hiroaki Yamamoto, Shota Mochizuki, Ryosuke Saio, Takashi Noguchi,Takeshi Oishi,Takaaki Sato,Noritaka Chida

Organic Letters（2022）

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摘要

The total synthesis of paclitaxel (Taxol) is described. Double Rubottom oxidation of the bis(silyl enol ether) derived from a tricarbocyclic diketone effectively installed a bridgehead olefin and C-5/C-13 hydroxy groups in a one-step operation. The novel Ag-promoted oxetane formation smoothly constructed the tetracyclic framework of paclitaxel.

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关键词

paclitaxel,total synthesis

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