Expression dynamics of the immune mediators ARG1, TBET, CIITA, IL10 and TGFB1 in chronic myeloid leukaemia patients during the first year of imatinib therapy

Gene(2022)

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摘要
•ARG1 was the only studied gene significantly elevated in CML patients at diagnosis.•ARG1 normalized to control levels at 3 months only in optimal responder patients.•TBET expression reached normal level after 12 months in both groups of patients.•CIITA expression continued downregulated during the first year of treatment.•IL10 and TGFB1 expression achieved normal levels early at 3 months in both groups.
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关键词
CML,Arginase-1,TBET,CIITA,Imatinib,Molecular response
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