Small-molecule profiling for steroid receptor activity using a universal steroid receptor reporter assay

Roy Eerlings,Nana Barbakadze,Tien Nguyen,Nanuli Nadaraia,Elien Smeets,Lisa Moris,Florian Handle,Sarah El Kharraz,Wout Devlies,Arnout Voet,Wim Dehaen,Frank Claessens,Christine Helsen

The Journal of Steroid Biochemistry and Molecular Biology（2022）

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摘要

•Combination of response elements for keto-steroid and estrogen receptors.•Universal steroid receptor reporter assay profiles small-molecules against all SRs.•Steroidal ketones as substrates for triazolization reactions.

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关键词

Aldo,AR,Dex,DHT,E2,ERα,ERβ,ERE,GR,KSRE,LBD,MR,Prog,PR,SAA,SR,SRE,T

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