Shared Molecular Mechanisms between Atherosclerosis and Periodontitis by Analyzing the Transcriptomic Alterations of Peripheral Blood Monocytes.

Wanchen Ning,Yihong Ma,Simin Li,Xin Wang,Hongying Pan,Chenxuan Wei,Shaochuan Zhang, Dongying Bai,Xiangqiong Liu,Yupei Deng,Aneesha Acharya,George Pelekos,Vuk Savkovic,Hanluo Li,Sebastian Gaus,Rainer Haak,Gerhard Schmalz,Dirk Ziebolz,Yanbo Ma,Yuzhen Xu

Computational and mathematical methods in medicine（2021）

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摘要

Exploration of available transcriptomic datasets revealed core crosstalk genes (RASGRP2, VAMP7, SNX3, HMGB1, SUMO1, SEC61G, PSMB2, SELPLG, and FIBP) and significant pathways (bacterial invasion of epithelial cells, platelet activation, and MAPK signaling) as top candidate molecular linkage mechanisms between atherosclerosis and periodontitis.

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