Contributions of obesity to kidney health and disease: insights from Mendelian randomization and the human kidney transcriptomics.

Xiaoguang Xu,James M Eales,Xiao Jiang,Eleanor Sanderson,Maciej Drzal,Sushant Saluja,David Scannali,Bryan Williams,Andrew P Morris,Tomasz J Guzik,Fadi J Charchar,Michael V Holmes,Maciej Tomaszewski

Cardiovascular research（2022）

引用 15|浏览22

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摘要

Our data show that a putatively causal association of obesity with renal health is largely independent of blood pressure and type 2 diabetes and uncover the signatures of obesity on the transcriptome of human kidney.

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关键词

Kidney disease,Kidney function,Kidney transcriptome,Mendelian randomization,Obesity

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