The association between prenatal perfluoroalkyl substance exposure and symptoms of attention-deficit/hyperactivity disorder in 8-year-old children and the mediating role of thyroid hormones in the Hokkaido study

Sachiko Itoh,Keiko Yamazaki,Satoshi Suyama,Atsuko Ikeda-Araki,Chihiro Miyashita,Yu Ait Bamai,Sumitaka Kobayashi,Hideyuki Masuda,Takeshi Yamaguchi,Houman Goudarzi,Emiko Okada,Ikuko Kashino,Takuya Saito,Reiko Kishi

Environment International（2022）

引用 9|浏览19

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摘要

•Higher the maternal PFAS levels, lower the risk of ADHD symptoms at 8 y of age.•Firstborn children showed more significant associations than second or later children.•Little mediating role of TH was found in the association of PFAS with reduced ADHD symptoms.

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关键词

Perfluoroalkyl substances,Neurodevelopment,Thyroid hormone,Mediation analysis,Birth cohort

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