The Origin and Contribution of Cancer-Associated Fibroblasts in Colorectal Carcinogenesis Hiroki Kobayashi , Krystyna A Gieniec , Tamsin R M Lannagan , Tongtong Wang , Naoya Asai , Yasuyuki Mizutani , Tadashi Iida , Ryota Ando , Elaine M Thomas , Akihiro Sakai , Nobumi Suzuki , Mari Ichinose , Josephine A Wright , Laura Vrbanac , Jia Q Ng , Jarrad Goyne , Georgette Radford , Matthew J Lawrence , Tarik Sammour , Yoku Hayakawa , Sonja Klebe , Alice E Shin , Samuel Asfaha , Mark L Bettington , Florian Rieder , Nicholas Arpaia , Tal Danino , Lisa M Butler , Alastair D Burt , Simon J Leedham , Anil K Rustgi , Siddhartha Mukherjee , Masahide Takahashi , Timothy C Wang , Atsushi Enomoto , Susan L Woods , Daniel L Worthley Gastroenterology（2022）
摘要
In colorectal cancer (CRC), tissue-resident LepR-lineage stromal cells are a major contributor to MCAM+ immunoregulatory cancer-associated fibroblasts. Understanding this stromal evolution has uncovered novel potential therapeutic targets for CRC.
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关键词
Colorectal Cancer, Tumor Microenvironment, Alpha-Smooth Muscle Actin (αSMA), CD146
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