Prevalence and temporal changes of mutations linked to antimalarial drug resistance in Plasmodium falciparum and Plasmodium vivax in Palawan, Philippines

International Journal of Infectious Diseases(2022)

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摘要
•Plasmodium falciparum and Plasmodium vivax isolates from the Philippines were analysed.•Varying mutations were found in markers linked to resistance to antimalarial drugs.•None of the mutations were particularly of high prevalence.•Clear temporal patterns in these mutations were observed within the past 15 years.•Decrease in pfcrt and pfmdr mutations are in line with antimalarial policy change.
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关键词
CQ,SP,AL,WHO,DHFR,DHPS,CRT,k13,MDR1,Pf,Pv,DNA,PCR,TES,rRNA
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