Trans-cinnamaldehyde suppresses microtubule detyrosination and alleviates cardiac hypertrophy

Jing Tian,Xiao-Li Shan,Si-Ning Wang,Hui-Hua Chen,Pei Zhao,Dong-Dong Qian,Ming Xu,Wei Guo,Chen Zhang,Rong Lu

European Journal of Pharmacology（2022）

引用 5|浏览7

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摘要

•Trans-cinnamaldehyde attenuates phenylephrine-induced cardiac hypertrophy in vitro and in vivo.•Trans-cinnamaldehyde normalizes phenylephrine-induced excessive tubulin detyrosination.•Trans-cinnamaldehyde restores phenylephrine-induced enhanced store-operated Ca2+ entry.•Trans-cinnamaldehyde rescues phenylephrine-induced calcium mishandling.

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关键词

Trans-cinnamaldehyde,Cardiac hypertrophy,Microtubule,Tubulin detyrosination,SOCE,Junctophilin-2

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