Ceftriaxone with Metronidazole versus Piperacillin/Tazobactam in the management of complicated appendicitis in children: Results from a multicenter pediatric NSQIP analysis

•In this study of 654 children with complicated appendicitis, the most common postoperative regimens were ceftriaxone with metronidazole and piperacillin/tazobactam•Rates of postoperative organ space infection were similar for patients who received ceftriaxone plus metronidazole and those who received piperacillin/tazobactam•Resource utilization was also similar between groups including 30-day postoperative imaging utilization, length of stay, and hospital cost