Metabolic profiling of charged metabolites in association with menopausal status in Japanese community-dwelling midlife women: Tsuruoka Metabolomic Cohort Study

•Evidence suggest that amino acids play key roles in obesity-related diseases.•Few studies have focused on amino acids and related metabolites in the specific context of menopause.•The association between menopausal status and charged metabolites was explored in over 1000 midlife women.•Multiple charged metabolites were associated with menopausal status.•Amongst the differentially expressed metabolites were those relevant to atherosclerosis.