Robust induction of neutralizing antibodies against the SARS-CoV-2 Delta variant after homologous Spikevax or heterologous Vaxzevria-Spikevax vaccination

Swantje I Hammerschmidt,Christoph Thurm,Berislav Bošnjak,Günter Bernhardt,Annegret Reinhold,Stefanie Willenzon,Christiane Ritter,Dirk Reinhold,Burkhart Schraven,Reinhold Förster

EUROPEAN JOURNAL OF IMMUNOLOGY（2022）

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摘要

Sera of vaccines were assessed by surrogate virus neutralization tests for their capacity to neutralize the SARS-CoV-2 Delta variant. Homologous prime-boost immunization with Moderna's Spikevax as well as heterologous immunization with AstraZeneca's Vaxzevria followed by Moderna's Spikevax were identified as highly potent vaccination regimens for the induction of Delta-neutralizing antibodies.

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关键词

antibodies, vaccination, SARS-CoV-2

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