Redefine Hyperprogressive Disease During Treatment With Immune-Checkpoint Inhibitors in Patients With Gastrointestinal Cancer.

Zhenghang Wang,Chang Liu,Yuezong Bai,Xiaochen Zhao,Longgang Cui,Zhi Peng,Xiaotian Zhang,Xicheng Wang,Zhengyi Zhao,Jian Li,Lin Shen

Frontiers in oncology（2021）

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摘要

Incorporating new lesions emerging during the treatment was shown to be reliable for the assessment of TGK. TGK serves as a more convenient way to reflect tumor growth acceleration compared with TGR. Genomic alterations were suggested to be associated with the occurrence of HPD.

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关键词

circulating tumor DNA,gastrointestinal cancer,hyperprogressive disease,immune checkpoint inhibitors,next-generation sequencing

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