Screening of the binding affinity of serum proteins to lipid nanoparticles in a cell free environment

•Time and cost-effective method for screening of serum protein binding to lipid nanoparticles based on Quartz Crystal Microbalance with Dissipation.•Sensor coating for detection of specific protein on a lipid-protein assembly.•Sensor coating for immobilisation of pegylated lipid assembly.•Lipid nanoparticle formulation affects serum protein binding affinity.