Androgen Excess Increases Food Intake in a Rat Polycystic Ovary Syndrome Model by Downregulating Hypothalamus Insulin and Leptin Signaling Pathways Preceding Weight Gain.

Neuroendocrinology(2022)

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摘要
Androgen excess increased food intake in rats and promoted obesity by downregulating insulin and leptin signaling in the hypothalamus, most likely by suppressing leptin levels in the CSF.
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关键词
Androgen excess,Food intake,Hypothalamus insulin sensitivity,Hypothalamus leptin sensitivity,Polycystic ovary syndrome
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