Conjugate word blending: formal model and experimental implementation by XPCR

NATURAL COMPUTING(2021)

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摘要
This paper introduces conjugate word blending as a formal model of molecular processes that occur during a DNA experimental protocol called cross-pairing Polymerase Chain Reaction (XPCR). We analyze this formal word and language operation from a computational viewpoint, by investigating closure properties of four Chomsky language families under it. We also report the molecular biology wet lab experiments based on XPCR amplification of gene sequences, which led to the notion of conjugate word blending.
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关键词
Conjugate word blending, Cross-pairing Polymerase Chain Reaction (XPCR), DNA computing, Gene assembly, Formal language operations, Molecular computing, Word blending, Word operations
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