The impact of quantity of lipid based formulations with different compositions on the oral absorption of ritonavir: A trade-off between apparent solubility and permeability

•An increase in LBF quantity reduced concentration of free drug in the GI tract.•The effect of LBF quantity on oral absorption depended on the LBF compositions.•Solubility-permeability trade-off is key factors for oral absorption from LBFs.•A new in vitro predictive tool successfully predicted oral absorption from LBFs.