Relationship between Amyloid-beta Deposition and the Coupling between Structural and Functional Brain Networks in Patients with Mild Cognitive Impairment and Alzheimer's Disease
BRAIN SCIENCES(2021)
摘要
Previous studies have demonstrated that the accumulation of amyloid-beta (A beta) pathologies has distinctive stage-specific effects on the structural and functional brain networks along the Alzheimer's disease (AD) continuum. A more comprehensive account of both types of brain network may provide a better characterization of the stage-specific effects of A beta pathologies. A potential candidate for this joint characterization is the coupling between the structural and functional brain networks (SC-FC coupling). We therefore investigated the effect of A beta accumulation on global SC-FC coupling in patients with mild cognitive impairment (MCI), AD, and healthy controls. Patients with MCI were dichotomized according to their level of A beta pathology seen in F-18-flutemetamol PET-CT scans-namely, A beta-negative and A beta-positive. Our results show that there was no difference in global SC-FC coupling between different cohorts. During the prodromal AD stage, there was a significant negative correlation between the level of A beta pathology and the global SC-FC coupling of MCI patients with positive A beta, but no significant correlation for MCI patients with negative A beta. During the AD dementia stage, the correlation between A beta pathology and global SC-FC coupling in patients with AD was positive. Our results suggest that A beta pathology has distinctive stage-specific effects on global coupling between the structural and functional brain networks along the AD continuum.
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关键词
amyloid-beta deposition, Alzheimer's disease, coupling between functional and structural networks, F-18-flutemetamol PET-CT, resting-state functional magnetic resonance imaging
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