IKZF1 deletions associate with CRLF2 overexpression leading to a poor prognosis in B-cell precursor acute lymphoblastic leukaemia

Ana Luiza Tardem Maciel,Thayana da Conceição Barbosa,Caroline Barbieri Blunck, Karolyne Wolch, Amanda de Albuquerque Lopes Machado,Elaine Sobral da Costa, Lavínia Lustosa Bergier, Márcia Trindade Schramm, Maura Rosane Valério Ikoma-Coltutato,Mecneide Mendes Lins,Thais Ferraz Aguiar,Marcela Braga Mansur,Mariana Emerenciano

Translational Oncology（2022）

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摘要

•CRLF2 overexpression associates with IKZF1 deletions that lead to a dominant-negative effect and with IKZF1 plus.•Paediatric patients with a high load expression of IK4 isoform presented higher CRLF2 transcript levels.•CRLF2 overexpression and IKZF1 deletions conferred poorer prognosis both to paediatric patients treated with RELLA05 protocol as well as to adult patients.

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关键词

CRLF2, IKZF1, Gene expression,Gene deletions,Outcome,B-ALL

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