Human amniotic fluid derived-exosomes alleviate hypoxic encephalopathy by enhancing angiogenesis in neonatal mice after hypoxia

Ping Li,Xiaoxu Lu,Jiajia Hu,Minhui Dai,Jianqin Yan,Huiling Tan, Peilin Yu,Xuliang Chen,Chengliang Zhang

Neuroscience Letters（2022）

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摘要

•HAFEXOs improved neurologic function in neonatal hypoxic mice by enhanced angiogenesis.•HAFEXOs enhanced the expression of HIF-1 α and VEGF in neonatal mice after hypoxia.•HAFEXOs improved promote tube formation and migration of HUVECs after OGD in vitro.

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关键词

Neonatal hypoxic encephalopathy,Exosomes,Neuroprotection,Angiogenesis,Neonatal mice,Hypoxia,Amniotic fluid

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