Novel Circulating Hypermethylated RASSF1A ddPCR for Liquid Biopsies in Patients With Pediatric Solid Tumors.

Lieke M J van Zogchel,Nathalie S M Lak, Onno J H M Verhagen, Ahmed Tissoudali, Mohammed Gussmalla Nuru,Nina U Gelineau,Lily Zappeij-Kannengieter, Ahmad Javadi,Eline A M Zijtregtop,Johannes H M Merks,Marry van den Heuvel-Eibrink,Antoinette Y N Schouten-van Meeteren,Janine Stutterheim,C Ellen van der Schoot,Godelieve A M Tytgat

JCO precision oncology（2021）

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摘要

Our findings demonstrate the value of ddPCR-based detection of hypermethylated as a circulating molecular tumor marker in neuroblastoma. Our preliminary investigation of hypermethylation detection in circulating cfDNA of other pediatric tumor entities demonstrates potential as a pan-tumor marker, but requires investigation in larger cohorts to evaluate its use and limitations.

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