Perturbed body fluid distribution and osmoregulation in response to high salt intake in patients with hereditary multiple exostoses

Jetta J Oppelaar,Nienke M G Rorije,Rik H G Olde Engberink,Youssef Chahid,Naomi van Vlies,Hein J Verberne,Bert-Jan H van den Born,Liffert Vogt

Molecular Genetics and Metabolism Reports（2021）

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摘要

HME patients show altered body fluid distribution and osmoregulation after HSD compared to controls. Our results might indicate reduced interstitial sodium accumulation capacity in HME, leading to ICFV increase. Therefore, this study provides additional support that HS is crucial for maintaining constancy of the internal environment.

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关键词

Sodium,Glycosaminoglycans,Heparan sulfate,Hereditary Multiple Exostoses,Water balance,Osmoregulation

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