Experimental Oronasal Transmission of Chronic Wasting Disease Agent from White-Tailed Deer to Suffolk Sheep

Eric D Cassmann,S Jo Moore,Justin J Greenlee

EMERGING INFECTIOUS DISEASES（2021）

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摘要

Chronic wasting disease (CWD) is a fatal prion disease of cervids. We examined host range of CWD by oronasally inoculating Suffolk sheep with brain homogenate from a CWD-positive white-tailed deer. Sixty months after inoculation, 1/7 sheep had immunoreactivity against the misfolded form of prion protein in lymphoid tissue. Results were confirmed by mouse bioassay.

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关键词

CWD,Suffolk sheep,animal diseases,chronic wasting disease,chronic wasting disease agent,experimental oronasal transmission,prions and related diseases,transmissible spongiform encephalopathies,white-tailed deer,zoonoses

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