DNAzyme-Based nanoflowers for reversing P-glycoprotein-mediated multidrug resistance in breast cancer

Linna Liang,Wendi Huo,Bei Wang,Lingzhi Cao,Haoran Huo,Yixin Liu,Yi Jin,Xinjian Yang

Journal of Colloid and Interface Science（2022）

引用 12|浏览4

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摘要

DNAzyme nanoflowers with satisfactory biocompatibility and gene silencing ability, constructed by rolling circle amplification (RCA) strategy, were applied in doxorubicin (Dox) delivery for efficiently ablating Dox-resistant breast cancer.

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关键词

DNAzyme,Gene silencing,P-glycoprotein,Multidrug resistance

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