The REPAIR Study: Effects of Macitentan on RV Structure and Function in Pulmonary Arterial Hypertension

Anton Vonk Noordegraaf,Richard Channick,Emmanuelle Cottreel,David G Kiely,J Tim Marcus,Nicolas Martin,Olga Moiseeva,Andrew Peacock,Andrew J Swift,Ahmed Tawakol,Adam Torbicki,Stephan Rosenkranz,Nazzareno Galiè

JACC: Cardiovascular Imaging（2022）

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摘要

In the context of this study, macitentan treatment in patients with PAH resulted in significant and clinically-relevant improvements in RV function and structure and cardiopulmonary hemodynamics. At 52 weeks, improvements in RV function and structure were sustained. (REPAIR: Right vEntricular remodeling in Pulmonary ArterIal hypeRtension [REPAIR]; NCT02310672).

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关键词

cardiac magnetic resonance,hemodynamics,macitentan,pulmonary arterial hypertension,right ventricle

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