Pet Imaging Of Type 5 Metabotropic Glutamate Receptors

This chapter describes the use of positron emission tomography (PET) for in vivo imaging of brain regional type 5 metabotropic glutamate (mGlu5) receptors. Two mGlu5 PET tracers have been well-validated, [C-11]ABP688 and [F-18]FPEB. They have been used, in laboratory animals and humans, to study diverse illnesses including Parkinson's disease, Alzheimer's disease, addictions, depression, and schizophrenia. The shorter half-life of [C-11]ABP688 makes it easier to conduct multiple scans on the same day in the same participant. The longer half-life of F-18-labeled tracers allows its use in centers without an on-site production facility. Additional details about each tracer's development, advantages, and disadvantages are described.