Peptides released from bovine α-lactalbumin by simulated digestion alleviated free fatty acids-induced lipid accumulation in HepG2 cells

Haoran Chen,Xiaofen Qi,Kaifang Guan,Yuxiang Gu,Rongchun Wang,Qiming Li,Ying Ma

Journal of Functional Foods（2021）

引用 12|浏览4

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摘要

•Peptides from α-LA decreased lipid accumulation in HepG2 cells.•The peptides of P2 (GINY) and P8 (DQW) acted as PPARα ligands.•P2 and P8 up-regulated genes expression of fatty acid β-oxidation in HepG2 cells.•P2 and P8 down-regulated genes expression of lipogenesis in HepG2 cells.

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关键词

α-lactalbumin,Peptide,Lipid metabolism,Molecular docking,PPARα

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