Study On The Antioxidant Properties Of Resveratrol In Oncology Prophylaxis

Cancer is a systemic disease with a huge plurality of clinical manifestations. Chemoprevention is a com-mon approach in this disease, constantly being inves-tigated many substances with prophylactic antitumor properties. Polyphenolic compounds, including resve-ratrol, have been extensively studied due to their anti-oxidant action, which is beneficial in chemopreven-tion. Resveratrol acts as an anticancer agent, suppre-ssing the metabolic activity of procarcinogens by mo-dulating the metabolic enzymes responsible for their activation and by activating antioxidant enzymes. In vitro and in vivo studies have shown that resveratrol can act as both a chemoprophylactic and a therapeutic agent, being involved in the inhibition of the three de-velopmental stages of neoplasia.The aim of this study was to evaluate the antioxi-dant effect of resveratrol, by evaluating three indices of oxidative stress, namely malondialdehyde (MDA), thiol groups (SH), and total antioxidants (AO), in Wistar rats that developed the Walker 256 tumour. The groups benefited from various treatment regimens that included, along with resveratrol, a chemothera-peutic. The results obtained in the study are in favour of the introduction of antioxidants in prophylaxis.