Autonomous Localization And Segmentation For Body Composition Quantization On Abdominal Ct

Objective: The impact of body composition on disease prognosis is increasingly recognized. Analysis of computed tomography (CT) scans at the level of the third lumbar (L3) spine is considered a standard approach to measure muscle and adipose tissue body composition parameters. However, existing approaches need manually select the L3 vertebra and then analyze body composition, which is time-consuming. Thus, how to automatically analyze body composition becomes the problem. Methods: In this paper, a novel two-step method is proposed and can automatically localize the L3 vertebra and segment body tissue accurately. Initially, the lumbar spine region is coarsely detected, and then each lumbar vertebra is determined. Secondly, the slice at the L3 vertebra is selected to quantize tissue (muscle, subcutaneous adipose tissue, visceral adipose tissue, etc.) based on a segmentation network. To achieve high performance, a Cross-Stage Attention (CSA) block and an adversarial structure are jointly utilized in tissue segmentation. Results: The experimental results show that the L3 vertebra localization result achieves 95.08% Dice. The CSA block and adversarial structure play positive roles in improving the tissue segmentation performance with an average Dice from 95.15% to 97.44%. Conclusion: The results demonstrate that our method outperforms other existing body tissue segmentation approaches in terms of sensitivity, positive predictive value (PPV), Dice score, and Jaccard score. Significance: The time cost of data collection and annotation can be significantly reduced due to integrating L3 vertebra localization before tissue segmentation. Simultaneously, our method can be extended to all lumbar vertebrae and quantize each tissue volume in the abdomen.