An Innovative Bioceramic Bone Graft With Platelet-Rich Plasma For Rapid Bone Healing And Regeneration In A Rabbit Model

This study aimed to investigate the effect of combining an innovative bioceramic alpha-calcium sulfate hemihydrate (alpha-CSH, CaSO4 center dot 0.5H(2)O) bone graft and platelet-rich plasma (PRP) to accelerate bone healing and regeneration in a rabbit model. The bone graft material was implanted bilaterally on rabbit's artificially maxillary sinus defects: the right maxillary sinus received alpha-CSH, while alpha-CSH combine with PRP (alpha-CSH/PRP) was grafted in left site. The quantity and quality of bone formation after implantation were analyzed radiographically and histologically at 1, 2, and 3 weeks. The micro-computed tomographic results indicated that the bone density of sinus implanted with alpha-CSH increased and defect volume decreased most after 2 weeks. In histological analysis, both hematoxylin and eosin and Masson trichrome staining of alpha-CSH/PRP displays better bone healing and regeneration progress than alpha-CSH after 2 weeks implantation. Therefore, the innovative alpha-CSH combined with PRP was revealed to be useful in accelerating bone healing and regeneration for the successful defect treatment.