Il-18: A Potential Inflammation Biomarker In Wiskott-Aldrich Syndrome

Elizabeth Rivers,Ying Hong,Mona Bajaj-Elliott,Austen Worth,Adrian J. Thrasher

EUROPEAN JOURNAL OF IMMUNOLOGY（2021）

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摘要

Analysis of serum cytokine levels in Wiskott-Aldrich syndrome patients pre- and post- treatment reveals IL-18 as a stable and reliable marker of inflammation. Definitive stem cell treatment with good myeloid correction correlates with resolution of inflammation and reduction of circulating IL-18, highlighting the importance of actin cytoskeletal regulation of myeloid cells in control of inflammation.

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关键词

Autoinflammation,IL-18,IL-1β,Inflammasome,Wiskott Aldrich syndrome

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