Stochastic optimization-based approach for simultaneous process design and HEN synthesis of tightly-coupled RO-ORC-HI systems under seasonal uncertainty

•A tightly-coupled RO-ORC-HI used for waste heat driven wastewater desalination.•The membrane performance improved by flexibly preheating wastewater.•The simultaneous stochastic process optimization and flexible HEN synthesis.•A finite set of correlated scenarios accounts for seasonal wastewater variability.