Electricity-Induced Micro-Flow C-H/N-H Alkyne Annulation: A Greener Approach To Access Heteroaromatic Compounds

Fast access to structurally diverse heteroaromatic compounds is demonstrated in an integrated continuous-flow manner without employing any expensive oxidant. The process involves an electro-flow heating reactor that uses electricity as the green oxidant to promote the reaction, leading to a fast (2 min) annulation reaction for the synthesis of heteroaromatic compounds.