Extensive Genetic And Phenotypic Description Of Mapt P.R406w In The Flanders-Belgian Population

We observed a nonconforming clinical phenotype of p.R406W carriers in the Flemish-Belgian cohort with 25.6 % bvFTD. Contrary to previous reports, prominent behavioral symptoms were highly frequent in the entire cohort (72.7%). Ages at onset and death varied widely but, intriguingly, correlated with clinical diagnosis, lower in bvFTD than AD phenotypes. CSF biomarkers showed some AD-like abnormalities.