Serum Uric Acid as a Putative Biomarker in Prodromal Parkinson's Disease: Longitudinal Data from the PPMI Study.

Christos Koros,Athina-Maria Simitsi,Nikolaos Papagiannakis,Anastasia Bougea,Andreas Prentakis,Dimitra Papadimitriou,Ioanna Pachi,Ion Beratis, Evangelia Stanitsa,Efthalia Angelopoulou,Roubina Antonelou, Marianna Bregianni, Konstantinos Lourentzos,Sokratis G Papageorgiou,Anastasios Bonakis,Xenia Geronicola Trapali,Maria Stamelou,Leonidas Stefanis

MOVEMENT DISORDERS（2023）

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摘要

Our results indicate that serum uric acid levels are higher in prodromal PD subjects with ongoing dopaminergic degeneration compared to those with manifest PD. These data indicate that the well-established decrease in the levels of serum uric acid occurs with the transition from prodromal to clinical PD. Whether the higher levels of serum uric acid observed in prodromal PD may provide protection against conversion to full-blown clinical PD will require further study.

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关键词

prodromal parkinsons,putative biomarker,acid

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