Cholinergic Agents - 2-Oxazolidinone Analogs Of The Acetylcholine-Receptor Muscarinic Agonist Pilocarpine

An oxazolidinone analogue of pilocarpine demonstrates muscarinic agonist-like properties in vitro at the acetylcholine-receptor. Replacement of the carbon alpha to the carbonyl in pilocarpine with a nitrogen represents the most active 2-oxazolidinone, comparable to pilocarpine. Further modifications abolished much of the activity, demonstrating the strict structure activity relationships intrinsic to this series.