Definition Of Organ Involvement And Treatment Response In Primary Systemic Amyloidosis (Al): A Consensus Opinion From The 10th International Symposium On Amyloid And Amyloidosis.

Introduction Previously, specific criteria for recognizing organ involvement and defining response in amyloid (AL) had minimal utility. However, new therapies directed at the plasma cell, including conventional dose chemotherapy, myeloablative chemotherapy, and agents directed at disruption of fibril structure are regularly being used to treat patients. Currently criteria for response and organ involvement differ from institution to institution, making it difficult to directly compare outcomes. Outcomes are directly related to the number of organs involved with amyloid and accurate definition as to what constitutes organ involvement are more than an academic exercise. Thirteen leaders in the field were invited to submit institutional criteria from which the current guidelines were developed.