Microwave Mediated Regioselective Synthesis Of Spiro Indolinone Library Via Multicomponent Reaction

This work explains an easy synthetic methodology to create a 25 member library of Hexahydrospiro[indoline-3,3'-pyrrolizine]-2-one derivatives under microwave irradiation. Spiro nucleus was synthesized via microwave mediated three component reaction of Isatin, L-proline and chalcone analogues in regioselective manner. A possible explanation for regioselectivity of present reaction was made by the discussion of secondary orbital interaction present in transition sate. Prepared spiroindolinone library were well characterized using all the spectroscopic data and elemental analysis. Thus we have developed a green and methodology that has great importance in synthetic chemistry.