Predictors Of In-Hospital Mortality For Sepsis Patients In Intensive Care Units

Sepsis is a major cause of death in patients in intensive care units. A better understanding of associations between patients' characteristics and in-hospital mortality for sepsis patients in intensive care units will help improve their outcomes. This study aims at investigating the predictors of in-hospital mortality for sepsis patients in intensive care units based on patients' characteristics and clinical evaluations. A single-center, retrospective study was performed based on data collected from patients in intensive care units of our affiliation hospital, from January 2010 to April 2014. General characteristics, respiratory function, blood routine examinations, liver and kidney functions, coagulation function, blood culture, C-reactive protein, procalcitonin, APACHE II score and SOFA score were recorded. The multiple logistic regression analysis was performed to analyze independent risk factors for in-hospital mortality and ROC curves were created. A total of 134 patients were enrolled and were further divided as nonsurvival group (n=38) and survival group (n=96). Decreased APACHE II score, total bilirubin, and platelet count were independently associated with in-hospital mortality for sepsis patients in intensive care units. The APACHE II score offered sensitive and specific predictive values, and platelet count and total bilirubin levels had some reference values for in-hospital mortality for sepsis patients in intensive care units. In conclusion, this study has demonstrated that APACHE II score could offer sensitive and specific predictive values for in-hospital mortality for sepsis patients in intensive care units.